| Autor: |
Mohamad Fekredeen Ayas, Ceren Durer, Seren Durer, Talal Adhami, Savio John |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
BMJ Open Gastroenterology, Vol 8, Iss 1 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2054-4774 |
| DOI: |
10.1136/bmjgast-2021-000648 |
| Popis: |
Background Hepatic encephalopathy (HE) is defined as brain dysfunction that occurs because of acute liver failure or liver cirrhosis and is associated with significant morbidity and mortality. Lactulose is the standard of care till this date; however, polyethylene glycol (PEG) has gained the attention of multiple investigators.Methods We screened five databases namely PubMed, Scopus, Web of Science, Cochrane Library and Embase from inception to 10 February 2021. Dichotomous and continuous data were analysed using the Mantel-Haenszel and inverse variance methods, respectively, which yielded a meta-analysis comparing PEG versus lactulose in the treatment of HE.Results Four trials with 229 patients were included. Compared with lactulose, the pooled effect size demonstrated a significantly lower average HE Scoring Algorithm (HESA) Score at 24 hours (Mean difference (MD)=−0.68, 95% CI (−1.05 to –0.31), p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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