| Autor: |
Davide Spica, Till Junker, Michael Dickenmann, Stefan Schaub, Jürg Steiger, Tanja Rüfli, Jörg Halter, Helmut Hopfer, Andreas Holbro, Patricia Hirt-Minkowski |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Case Reports in Nephrology and Dialysis, Vol 9, Iss 3, Pp 149-157 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2296-9705 |
| DOI: |
10.1159/000503951 |
| Popis: |
We report the effectiveness of daratumumab, a human IgGκ monoclonal antibody targeting CD38 on plasma cells, for therapy-refractory antibody-mediated rejection (AMR) due to blood group antibodies in a 59-year-old man who received a living ABO-incompatible kidney transplantation. Standard treatment options for AMR due to blood group antibodies including immunoadsorption, lymphocyte depletion with anti-human T-lymphocyte globulins, intravenous methylprednisolone pulses and eculizumab limited tissue injury, however failed to sufficiently suppress blood group antibody production. After administration of daratumumab as a rescue therapy, blood group antibody titers decreased and remained at low levels without further immunoadsorption and allowed kidney graft function to recover. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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