EVIDENCE FOR A 12 kDa 'CARRIER PROTEIN' FOR NATRIURETIC HORMONE

Autor:	Harvey Craig Gonick
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Carrier Proteins Hormones Hypertension review Anf natriuretic hormone Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	Frontiers in Endocrinology, Vol 5 (2014)
Druh dokumentu:	article
ISSN:	1664-2392
DOI:	10.3389/fendo.2014.00196
Popis:	The search for the elusive natriuretic hormone continues. In this review evidence is presented that isolating the carrier protein for natriuretic hormone is a necessary first step before splitting off the final hormone. The carrier protein has a molecular weight of 12 kDa while the final hormone has a molecular weight of 408 daltons. Both compounds inhibit Na-K-ATPase but the compound containing the carrier protein predominates. The question has been raised as to whether the carrier protein is in actuality proANF, a 17 kDa protein that can be split between a 14 kDa protein (the presumptive proANF) and the 3 kDa ANF.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/284d6a3e6ad04961baade55c9cbba63d Zobrazit plný text záznamu View record in DOAJ