Haplogroup diversity in the Indian population using 23 Y-STRs

Autor: Pankaj Shrivastava, Muktikanta Panda, Kamlesh Kaitholia, Shivani Dixit, Ramkishan Kumawat, Hari Shankar, A. N. Sharma, Gyaneshwer Chaubey
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Annals of Human Biology, Vol 49, Iss 3-4, Pp 200-203 (2022)
Druh dokumentu: article
ISSN: 0301-4460
1464-5033
03014460
DOI: 10.1080/03014460.2022.2091796
Popis: Background A Y-STR polymorphism study is a convenient tool in molecular anthropology and forensic DNA analysis. Aim Through standard ethical procedures, the proposed study explored the genetic scenario in male lineage in Madhya Pradesh, a central Indian state, by Y-STR genotyping and haplogroup studies. Subjects and methods Five hundred and eleven unrelated male blood samples were directly amplified, and fragment separation was done using capillary electrophoresis to generate a Y-STR profile for 23 forensic relevant markers through PowerPlex® Y 23 multiplex system. The different statistical methods were applied for studying the forensic and genetics parameters. Subsequently, population comparison was performed by AMOVA, PCoA, and MDS plot, and Haplogroups were predicted with Whit Athey's haplogroup predictor tool. Conclusion These data represented the potential value of the PowerPlex® Y-23 multiplex system for the forensic and human genetics application in the population of Madhya Pradesh, India. Simultaneously the Haplogroup analysis revealed information about the multi-geographic origin as well as multi-ethnic genetic affinities of the Madhya Pradesh population.
Databáze: Directory of Open Access Journals
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