Nestin-dependent mitochondria-ER contacts define stem Leydig cell differentiation to attenuate male reproductive ageing

Autor: Senyu Yao, Xiaoyue Wei, Wenrui Deng, Boyan Wang, Jianye Cai, Yinong Huang, Xiaofan Lai, Yuan Qiu, Yi Wang, Yuanjun Guan, Jiancheng Wang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-31755-w
Popis: The regulatory mechanisms contributing to male reproductive ageing are unknown. Here, the authors show that Nestin-dependent mito-ER contacts (MERCs) regulate stem Leydig cell (SLC) senescence and provide insights into SLCs-targeting therapies.
Databáze: Directory of Open Access Journals