Effects of gabapentin on slow‐wave sleep period in critically ill adult patients: A randomized controlled trial

Autor: Kanyarat Susantitapong, Pitchaya Dilokpattanamongkol, Yuda Sutherasan, Somprasong Liamsombut, Chuthamanee Suthisisang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Clinical and Translational Science, Vol 17, Iss 5, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 1752-8062
1752-8054
DOI: 10.1111/cts.13815
Popis: Abstract Sleep deprivation is a prevalent problem in critically ill patients, which leads to delayed recovery and delirium. Slow‐wave sleep (SWS) is essential to energy restoration, tissue repair, and immune system strengthening. This study aimed to investigate the effects of gabapentin on SWS in critically ill patients. We performed a prospective open‐label randomized controlled study to compare SWS and the clinical outcomes of gabapentin versus a control intervention in critically ill adult patients admitted to the intensive care unit (ICU) within 24 h. The patients' characteristics and sleep‐related outcomes were recorded. The sleep‐related outcomes, namely, bispectral analysis (BIS), the Richards‐Campbell Sleep Questionnaire (RCSQ), and insulin‐like growth factor‐1 (IGF‐1) levels, were evaluated. Furthermore, clinical outcomes and safety were assessed. Sixty patients from 348 cases were eligible for randomization. On day 3 of the study, patients in the gabapentin group had significantly increased SWS (66.79 vs. 0.00 min; p
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