Diagnostic and prognostic value of proadrenomedullin in neonatal sepsis
Autor: | Sameh Samir Fahmey, Heba Mostafa, Noha Abd Elhafeez, Heba Hussain |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: | |
Zdroj: | Korean Journal of Pediatrics, Vol 61, Iss 5, Pp 156-159 (2018) |
Druh dokumentu: | article |
ISSN: | 1738-1061 2092-7258 |
DOI: | 10.3345/kjp.2018.61.5.156 |
Popis: | PurposeSepsis is a major cause of neonatal morbidity and mortality. Early diagnosis is a major problem because of the lack of specific clinical signs. Therefore, a reliable diagnostic marker is needed to guide the use of antimicrobial agents. The objective of our study was to assess the value of proadrenomedullin (pro-ADM) in establishing the diagnosis and evaluating the prognosis of neonatal sepsis.MethodsThis study enrolled 60 newborn infants with sepsis proven with positive blood cultures and 30 healthy neonates. Complete blood count, C-reactive protein levels, and pro-ADM levels were obtained from all neonates.ResultsThe pro-ADM levels were significantly higher (14.39±0.75 nmol/L) in the sepsis group than in the control group (3.12±0.23 nmol/L). The optimal cutoff value for pro-ADM was 4.3 nmol/L, with a sensitivity of 93.3% and a specificity of 86.7%. The pro-ADM levels were also higher in nonsurvivors (P=0.001).ConclusionPro-ADM can be used as a reliable biomarker for neonatal sepsis. High pro-ADM levels were associated with mortality and could be an early indicator of disease outcome. |
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