| Autor: |
Claudia Hernández-Jiménez, Javier Martínez-Cortés, J. Raúl Olmos-Zuñiga, Rogelio Jasso-Victoria, María Teresa López-Pérez, Néstor Emmanuel Díaz-Martínez, Marcelino Alonso-Gómez, Axel Edmundo Guzmán-Cedillo, Matilde Baltazares-Lipp, Miguel Gaxiola-Gaxiola, Adriana Méndez-Bernal, Adrián Polo-Jeréz, Juan Carlos Vázquez-Minero, Oscar Hernández-Pérez, Christopher O. Fernández-Solís |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-12 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2466 |
| DOI: |
10.1186/s12890-023-02619-w |
| Popis: |
Abstract Background Ex vivo lung perfusion (EVLP) constitutes a tool with great research potential due to its advantages over in vivo and in vitro models. Despite its important contribution to lung reconditioning, this technique has the disadvantage of incurring high costs and can induce pulmonary endothelial injury through perfusion and ventilation. The pulmonary endothelium is made up of endothelial glycocalyx (EG), a coating of proteoglycans (PG) on the luminal surface. PGs are glycoproteins linked to terminal sialic acids (Sia) that can affect homeostasis with responses leading to edema formation. This study evaluated the effect of two ex vivo perfusion solutions on lung function and endothelial injury. Methods We divided ten landrace swine into two groups and subjected them to EVLP for 120 min: Group I (n = 5) was perfused with Steen® solution, and Group II (n = 5) was perfused with low-potassium dextran-albumin solution. Ventilatory mechanics, histology, gravimetry, and sialic acid concentrations were evaluated. Results Both groups showed changes in pulmonary vascular resistance and ventilatory mechanics (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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