Unusual CD34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation

Autor: Daniele Avenoso, Pramila Krishnamurthy, Jonathan Salisbury, Sabia Rashid, Shreyans Gandhi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: eJHaem, Vol 2, Iss 4, Pp 899-900 (2021)
Druh dokumentu: article
ISSN: 2688-6146
DOI: 10.1002/jha2.289
Popis: Abstract Acute megakaryoblastic leukaemia is a rare entity with distinct immunophenotype profile and cytogenetic lesions. Herein, we report a case of acute myeloid leukaemia with myelodysplastic‐related changes with megakaryoblastic differentiation in absence of recurrent genomic lesions such as t(1;22), inv(3) and t(3;3). One of the peculiarities of this case is the positivity of CD34+ within the abnormal megakaryoblasts; CD61 immunohistochemistry highlights the heavily infiltration of bone marrow from abnormal megakaryoblasts.
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