Inhibitory effect of ultrasonicated sesame meal on fat accumulation of 3T3-L1 adipocytes and oleic acid induced HepG2 hepatocytes

Autor: Ji-Eun Kim, Ji-Yun Bae, Mi-Ja Kim
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Functional Foods, Vol 117, Iss , Pp 106239- (2024)
Druh dokumentu: article
ISSN: 1756-4646
DOI: 10.1016/j.jff.2024.106239
Popis: Antioxidant activities of an aqueous extract of sesame meal (SM-HW) and an ultrasonicated sesame meal (SSM-HW) were evaluated and anti-obesity activity of SSM-HW was determined using in vitro assays. In addition, metabolite analyses were conducted using GC/MS to determine major non-volatile compounds in SM-HW and SSM-HW. Antioxidant activities of SSM-HW were significantly higher than those of SM-HW. SSM-HW had higher concentrations of some organic acids and amino acids than SM-HW. Differentiation of 3T3-L1 adipocytes was decreased by 20 % after treatment with 10 μg/mL SSM-HW compared to control. Expression levels of several adipocyte marker genes and proteins were significantly decreased compared to control (p
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