| Autor: |
I. Kralova Lesna, P. Suchanek, J. Kovar, P. Stavek, R. Poledne |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Journal of Lipid Research, Vol 49, Iss 11, Pp 2414-2418 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
0022-2275 |
| DOI: |
10.1194/jlr.M800271-JLR200 |
| Popis: |
Dietary intervention is the first and usually successful approach in the treatment of high LDL cholesterol (LDL-C) concentration, but it is frequently accompanied by a decrease in HDL concentration. We studied 14 male volunteers on two different diets, high saturated fatty acid (SFA) and high PUFA, in a crossover design to test whether a decrease in HDL can affect reverse cholesterol transport from relabeled macrophages. A significant decrease of LDL-C (in mmol/l) after a PUFA diet compared with an SFA diet from 3.15 ± 0.65 to 2.80 ± 0.56 (P < 0.01) was accompanied by a significant decrease of HDL cholesterol (HDL-C) (in mmol/l) from 1.21 ± 0.30 to 1.10 ± 0.32 (P < 0.05). These changes did not affect cholesterol efflux (CHE) from macrophages (9.74 ± 1.46% vs. 9.53 ± 1.41%). There was no correlation between individual changes of HDL-C and changes of CHE. It is concluded that the decrease of HDL-C after successful dietary intervention of LDL-C is not accompanied by a decrease of CHE. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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