| Autor: |
Mariana Q. S. Soares, Jeroen Van Dessel, Reinhilde Jacobs, Gustavo Z. Ferreira, Paulo Sérgio daSilva Santos, Laura F. P. Nicolielo, Marco A. H. Duarte, Izabel R. F. Rubira‐Bullen |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinical and Experimental Dental Research, Vol 8, Iss 6, Pp 1487-1495 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2057-4347 |
| DOI: |
10.1002/cre2.643 |
| Popis: |
Abstract Objectives The aim of this study is to investigate the long‐term effects on jaw and femur bone induced by oncologic doses of zoledronic acid in a young rat model. Material and Methods Six 12‐week‐old male Wistar rats received zoledronic acid (0.6 mg/kg) and six control rats received saline solution in the same volume. Compounds were administered intraperitoneally in five doses every 28 days. Euthanasia was performed 150 days after therapy onset. After animal sacrifice, their mandibles and femurs were scanned ex vivo using a high‐resolution (14 μm) micro‐computed tomography. Morphometric bone parameters were calculated using CT‐Analyzer (Bruker, Belgium) between the first and second mandibular molars and in the distal femur metaphysis and epiphysis. Results The treatment group as compared to the controls showed a significantly (p |
| Databáze: |
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| Externí odkaz: |
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