Modulation of plasma triglycerides concentration by sterol-based treatment in subjects carrying specific genes
| Autor: | Ismael San Mauro Martin, Javier Andrés Blumenfeld Olivares, Elena Garicano Vilar, María José Ciudad Cabañas, Luis Collado Yurrita |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Research in Cardiovascular Medicine, Vol 8, Iss 3, Pp 69-75 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2251-9572 2251-9580 |
| DOI: | 10.4103/rcm.rcm_10_19 |
| Popis: | Introduction: Genetic load may indirectly influence on cardiovascular risk. This work aimed to analyze the influence of polymorphisms (APOA5 C56G-Ser19Trp, Prothrombin-G20210A, F5 Arg506Gln, MTHFR-C677T, LIPC-C-514T, LPA-I4300M, PPAR_ALPHA-L162V, APOA5-1131T > C, APOE-APOE2/3/4, and APOE-APOE2,3,4) in plasma triglyceride (TG) levels of patients ingesting plant sterols. Materials and Methods: Double-blind, crossover, controlled clinical trial was performed in 45 individuals (25 women). About 2.24 g sterols in milk and placebo milk were ingested daily during 3 weeks each, separated by a 2-week washout period. Blood draws and saliva genomic DNA was extracted. Results: APOA5-C56G-Ser19Trp, MTHFR-C677T, and PPAR_ALPHA-L162V greatly benefit from sterols intake. APOA5-C56G-Ser19Trp GG homozygous carriers lowered their TGs more than CG heterozygote carriers (P = 0.003). TT homozygous carriers of gene LIPC C-514T experienced an increase of TGs. Conclusions: Further studies are needed to establish which genotype combinations is the most protective against hypertriglyceridemia. |
| Databáze: | Directory of Open Access Journals |
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