Salidroside and exercise performance in healthy active young adults – an exploratory, randomized, double-blind, placebo-controlled study

Autor: Neil A. Schwarz, Matthew T. Stratton, Ryan J. Colquhoun, Alexia M. Manganti, Margaux Sherbourne, Florian Mourey, Caitlyn C. White, Heather Day, Micaela C. Dusseault, Geoffrey M. Hudson, Christopher R. Vickery, Holly C. Schachner, Philip G. Kasprzyk, Jing-Ke Weng
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of the International Society of Sports Nutrition, Vol 21, Iss 1 (2024)
Druh dokumentu: article
ISSN: 15502783
1550-2783
DOI: 10.1080/15502783.2024.2433744
Popis: Background Rhodiola rosea extract is purported to improve physical performance and support resilience to stress. Salidroside is considered to be one of the main constituents responsible for the ergogenic actions of R. rosea. However, R. rosea extract contains relatively little salidroside and cultivation of R. rosea is challenging as it is mainly found in high-altitude, cold regions. Additionally, the R. rosea plant is subject to conservation concerns because of its growing popularity. The purpose of this exploratory study was to evaluate the short-term effects of pure, biosynthetic salidroside supplementation on exercise performance, mood state, and markers of inflammation and muscle damage in healthy active young adults.Methods Fifty participants (30 M, 20F; 21 ± 4 yrs; 173 ± 8 cm; 74 ± 13 kg) were randomly assigned to either salidroside (60 mg/day for 16 days) or placebo supplementation and underwent peak oxygen uptake (VO2 peak), intermittent time-to-exhaustion (TTE), and local muscular endurance assessments, along with mood state evaluations using the Profile of Mood States (POMS). Blood samples were analyzed for erythropoietin, myoglobin, creatine kinase-MM, and C-reactive protein.Results Salidroside supplementation enhanced overall percent predicted oxygen uptake during high-intensity intermittent exercise (p
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