A single-molecule view of telomerase regulation at telomeres

Autor: Pascal Chartrand, Agnel Sfeir
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)
Druh dokumentu: article
ISSN: 2372-3556
23723556
23170786
DOI: 10.1080/23723556.2020.1818537
Popis: Telomerase plays a key role in the immortalization of cancer cells by maintaining telomeres length. Using single-molecule imaging of telomerase RNA molecules in cancer cells, we recently reported novel insights into the role of Cajal bodies in telomerase biogenesis and the regulation of telomerase recruitment to telomeres.
Databáze: Directory of Open Access Journals
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