Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers

Autor: Lorena Zuliani-Alvarez, Anna M. Marzeda, Claire Deligne, Anja Schwenzer, Fiona E. McCann, Brian D. Marsden, Anna M. Piccinini, Kim S. Midwood
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-017-01718-7
Popis: Although detection of pathogens by pattern recognition receptors is increasingly well defined, recognition of endogenous triggers remains poorly understood. By examining the interface between tenascin-C and TLR4, the authors identify a molecular code that identifies endogenous proteins as inflammatory stimuli.
Databáze: Directory of Open Access Journals