| Autor: |
D S Henriquez, H M Tepperman, J Tepperman |
| Jazyk: |
angličtina |
| Rok vydání: |
1979 |
| Předmět: |
|
| Zdroj: |
Journal of Lipid Research, Vol 20, Iss 5, Pp 624-630 (1979) |
| Druh dokumentu: |
article |
| ISSN: |
0022-2275 |
| DOI: |
10.1016/S0022-2275(20)40585-1 |
| Popis: |
Purified liver plasma membranes were prepared from rats fed a high-fat, carbohydrate-free diet or a high-glucose, fat-free diet. Membranes from rats fed the high-fat diet bound significantly less 125I-labeled concanavalin A (Con A) than did those from rats fed the fat-free diets. The magnitude of the binding difference increased with increasing concentrations of Con A. Neither association nor dissociation rates of the lectin-receptor complex was affected by diet. The extent of degradation of Con A by liver plasma membrane preparations from rats fed either diet was the same. Chemical analysis of delipidated liver plasma membrane showed that membranes prepared from high-fat diet-adapted rats had significantly lower values for all carbohydrate components measured with the exception of galactose. The results indicate that, in liver cells, a change in plasma membrane glycoproteins is part of the complex adaptation to altered diet composition. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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