The Use of Crizotinib in Sclerosing Epithelioid Fibrosarcoma with ALK Mutation: A Case Report

Autor:	Ahmed Badran, Clara Steele, Hisham Alquaydheb, Ahmed Ba Theeb, Abdulmalek Bawazir, Mahmoud A. Elshenawy, Jean Paul Atallah
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	sclerosing epithelioid fibrosarcoma anaplastic lymphoma kinase mutation crizotinib Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Case Reports in Oncology, Vol 16, Iss 1, Pp 746-752 (2023)
Druh dokumentu:	article
ISSN:	1662-6575
DOI:	10.1159/000532099
Popis:	Sclerosing epithelioid fibrosarcoma is an ultra-rare and aggressive high-grade fibrosarcoma that was originally described in 1995. More than 100 cases are documented worldwide, with the most extensive case series reporting a high rate of recurrence and metastasis. ALK mutations are commonly seen in soft-tissue sarcomas; however, this is the first known case of an ALK V757M mutation. Here, we present a case using crizotinib in treating an ALK-positive sclerosing epithelioid fibrosarcoma refractory to all traditional treatment options.
Databáze:	Directory of Open Access Journals
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