| Autor: |
Carlo Mümmler, Kristin Dünzelmann, Nikolaus Kneidinger, Michaela Barnikel, Dieter Munker, Moritz Gröger, Martin Canis, Jürgen Behr, Andrea Koch, Frank Haubner, Katrin Milger |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Clinical and Translational Allergy, Vol 11, Iss 5, Pp n/a-n/a (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-7022 |
| DOI: |
10.1002/clt2.12049 |
| Popis: |
Abstract Background We aimed to evaluate the effectiveness of different antibody therapies on nasal polyp symptoms in patients treated for severe asthma. Methods We performed a retrospective analysis of patients with severe asthma and comorbid CRSwNP who were treated with anti‐IgE, anti‐IL‐5/R or anti‐IL‐4R. CRSwNP symptom burden was evaluated before and after 6 months of therapy. Results Fifty patients were included hereof treated with anti‐IgE: 9, anti‐IL‐5/R: 26 and anti‐IL‐4R: 15 patients. At baseline median SNOT‐20 was similar among groups (anti‐IgE: 55, anti‐IL‐5/R: 52 and anti‐IL‐4R: 56, p = 0.76), median visual analogue scale (VAS) for nasal symptoms was 4, 7 and 8 (p = 0.14) and VAS for total symptoms was higher in the anti‐IL‐4R group (4, 5 and 8, p = 0.002). After 6 months SNOT‐20 improved significantly in all patient groups with median improvement of anti‐IgE: −8 (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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