SMYD2 promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and SMYD2 expression in vascular smooth muscle cells

Autor: Bradley J. Toghill, Athanasios Saratzis, Peter J. Freeman, Nicolas Sylvius, UKAGS collaborators, Matthew J. Bown
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Clinical Epigenetics, Vol 10, Iss 1, Pp 1-15 (2018)
Druh dokumentu: article
ISSN: 1868-7075
1868-7083
DOI: 10.1186/s13148-018-0460-9
Popis: Abstract Background Abdominal aortic aneurysm (AAA) is a deadly cardiovascular disease characterised by the gradual, irreversible dilation of the abdominal aorta. AAA is a complex genetic disease but little is known about the role of epigenetics. Our objective was to determine if global DNA methylation and CpG-specific methylation at known AAA risk loci is associated with AAA, and the functional effects of methylation changes. Results We assessed global methylation in peripheral blood mononuclear cell DNA from 92 individuals with AAA and 93 controls using enzyme-linked immunosorbent assays, identifying hyper-methylation in those with large AAA and a positive linear association with AAA diameter (P
Databáze: Directory of Open Access Journals
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