Chronic preclinical safety evaluation of HematideTM, a pegylated peptidic erythropoiesis stimulating agent in monkeys

Autor:	Kathryn W. Woodburn, Susan D. Wilson, Kei-lai Fong, Peter J. Schatz, Thomas Ferrell, Charles B. Spainhour, Daniel Norton
Jazyk:	angličtina
Rok vydání:	2008
Předmět:	Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Haematologica, Vol 93, Iss 9 (2008)
Druh dokumentu:	article
ISSN:	0390-6078 1592-8721
DOI:	10.3324/haematol.12896
Popis:	Hematide is a synthetic peptide-based, pegylated erythropoiesis stimulating agent in clinical development for treatment of anemia. To support chronic clinical dosing requirements, a 9-month repeat dose IV monkey safety study was undertaken. Animals received 0, 0.2, 2 or 20 mg/kg hematide IV every three weeks for nine months followed by a 14-week recovery. Hematide administration was associated with time and dose-dependent polycythemia. Histological findings were related to exaggerated pharmacology that was secondary to the administration of an erythropoiesis stimulating agent to a normocythemic animal. In conclusion, these results support the use of repeated administration of hematide for the correction of anemia.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/27d4a681f09545cfafa1e77b0afce10b Zobrazit plný text záznamu View record in DOAJ