Successful Treatment of a Patient with anti-PD1 Antibody-Resistant Advanced Mucosal Melanoma with Nivolumab, Ipilimumab plus Denosumab Combination Therapy

Autor:	Taku Fujimura, Yumi Kambayashi, Kentaro Ohuchi, Ryo Amagai, Yota Sato, Kayo Tanita, Akira Hashimoto, Setsuya Aiba
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	mucosal melanoma bone metastasis nivolumab plus ipilimumab combination therapy denosumab Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Case Reports in Oncology, Vol 13, Iss 1, Pp 271-275 (2020)
Druh dokumentu:	article
ISSN:	1662-6575
DOI:	10.1159/000506327
Popis:	Since the incidence of mucosal melanoma is higher in the Japanese population compared to Caucasians, and since mucosal melanoma possesses a lower mutation burden compared to cutaneous melanoma, the efficacy of anti-PD1 antibody (Ab) monotherapy for mucosal melanoma is limited. Therefore, other targeting molecules that enhance the anti-tumor effects of immune checkpoint inhibitors are needed. In this report, we present a case with anti-PD1 Ab-resistant recurrent malignant melanoma of the nasal cavity successfully treated with nivolu­mab, ipilimumab plus denosumab combination therapy.
Databáze:	Directory of Open Access Journals
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