A Concise Diastereoselective Total Synthesis of α-Ambrinol
| Autor: | Josefa L. López-Martínez, Irene Torres-García, Irene Moreno-Gutiérrez, Pascual Oña-Burgos, Antonio Rosales Martínez, Manuel Muñoz-Dorado, Míriam Álvarez-Corral, Ignacio Rodríguez-García |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Marine Drugs, Vol 21, Iss 4, p 230 (2023) |
| Druh dokumentu: | article |
| ISSN: | 21040230 1660-3397 |
| DOI: | 10.3390/md21040230 |
| Popis: | (−)-cis-α-Ambrinol is a natural product present in ambergris, a substance of marine origin that has been highly valued by perfumers. In this paper, we present a new approach to its total synthesis. The starting material is commercially available α-ionone and the key step is an intramolecular Barbier-type cyclization induced by CpTiCl2, an organometallic compound prepared in situ by a CpTiCl3 reduction with Mn. |
| Databáze: | Directory of Open Access Journals |
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