The effects of highly bioavailable curcumin in downhill running-induced muscle damage model

Autor: Yu Seon Kim, Bongki Cho, Sang-Heon Kim, Byoung-Gon Moon, Yun-Il Lee
Jazyk: English<br />Spanish; Castilian
Rok vydání: 2024
Předmět:
Zdroj: CyTA - Journal of Food, Vol 22, Iss 1 (2024)
Druh dokumentu: article
ISSN: 19476337
1947-6345
1947-6337
DOI: 10.1080/19476337.2024.2353320
Popis: Curcumin is a natural polyphenolic compound exerting antioxidative and anti-inflammatory effects on various tissues, including muscles. Nevertheless, its clinical usage has been limited because of its poor bioavailability. Thus, highly bioavailable curcumin, such as Theracurmin (CR-033P) composed of 36% crystalline curcumin, has been developed. This study investigated the antioxidant activity and muscle-protective effect of Theracurmin Super (TS-P1), a new formulation with 36% amorphous curcumin. TS-P1 and CR-033P demonstrated antioxidant activity in vitro. Compared with pure curcumin, orally administered TS-P1 or CR-033P (16.7 or 50 mg per kg of body weight) at one-third dose inhibited the elevation of plasma lactate dehydrogenase and creatine kinase levels in a mouse downhill running model, indicating superior muscle-protective effect. Particularly, TS-P1 showed better or equivalent effectiveness in restoring the activity of antioxidant enzymes including glutathione peroxidase and catalase, and in suppressing inflammatory responses. Therefore, formulation with amorphous curcumin is a promising strategy for curcumin-based supplements.
Databáze: Directory of Open Access Journals
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