Endothelial progenitor cells and vascular endothelial growth factor after endovascular interventions in patients with type 2 diabetes

Autor: Marina Sergeevna Michurova, Victor Yurievich Kalashnikov, Olga Michailovna Smirnova, Sergey Anatol'evich Terekhin, Olga Nikolaevna Ivanova, Svetlana Michailovna Stepanova, Aleksandr Victorovich Ilin, Ivan Ivanovich Dedov
Jazyk: English<br />Russian
Rok vydání: 2017
Předmět:
Zdroj: Сахарный диабет, Vol 20, Iss 1, Pp 59-67 (2017)
Druh dokumentu: article
ISSN: 2072-0351
2072-0378
DOI: 10.14341/DM8173
Popis: Aim. To study the quantity of endothelial progenitor cells (EPCs) and levels of vascular endothelial growth factor A (VEGF-A) in patients with type 2 diabetes mellitus (T2DM) after endovascular interventions on coronary and peripheral arteries. Materials and methods. We observed 68 patients with stable angina pectoris and critical limb ischaemia, admitted for elective percutaneous coronary intervention and endovascular revascularisation of the lower extremity. The number of CD34+VEGFR2+CD45- and CD34+CD133+CD45- cells and levels of VEGF-A were determined before endovascular intervention and 2–4 days after the surgery. Results. We found that in patients without diabetes, the levels of EPCs increased significantly after endovascular interventions (CD34+VEGFR2+CD45-cells, p < 0.0001; CD34+ CD133+CD45-cells p = 0.041). The levels of EPCs in the peripheral blood of patients with T2DM before and after endovascular interventions did not significantly differ. The analysis of VEGF-A showed a statistically significant increase after intervention in both groups. In addition, in patients with an HbA1c level of 10 years, the levels of EPCs before and after endovascular interventions did not significantly differ. Conclusions. Patients with diabetes exhibited impaired EPC mobilisation after endovascular interventions. Poor glycaemic control and a long duration of diabetes are among the risk factors of EPC mobilisation.
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