Silk sericin-based functional food for osteoporosis prevention and therapy

Autor: Xian Jin, Xiangguo Che, Dong-Kyo Lee, Ying Cui, Poo-Reum Choi, Hyun-Ju Kim, Ji Hae Lee, HaeYong Kweon, Seong-Gon Kim, Je-Yong Choi
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Functional Foods, Vol 116, Iss , Pp 106148- (2024)
Druh dokumentu: article
ISSN: 1756-4646
DOI: 10.1016/j.jff.2024.106148
Popis: The development of new functional foods that can potentially reduce the risk of diseases, such as osteoporosis, has received increasing attention in recent years. Here we demonstrated that silk sericin-based functional food (SSBF) exerted preventive and therapeutic effects against bone loss. Sericin isolated at 70 °C for 60 min from the cocoon of Bombyx mori stimulated osteoblast differentiation by increasing osteoblastic gene expression while inhibiting receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation in vitro. Micro-computed tomography analysis revealed that pre- and post-oral administration of SSBF increased bone mass in ovariectomized mouse model in vivo. Furthermore, dynamic bone histomorphometry analysis revealed that SSBF enhanced osteoblast activity and suppressed bone resorption by reducing the number of osteoclasts. These findings indicated the potential role of SSBF in preventing and being a therapeutic candidate for osteoporosis.
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