Predictors of medication regimen complexity and its impact on hemoglobin a1c in type 2 diabetes patients: a retrospective analysis in ambulatory care in Makkah City

Autor: Sarah M. Khayyat, Ruba S. Azfr Ali, Hanadi H. Alrammaal, Salwa M.S. Khayyat, Wafaa A. Alqurashi, Reemaz Alsaedi, Wejdan Alotaibi, Aseel Alahmadi
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Annals of Saudi Medicine, Vol 44, Iss 5, Pp 296-305 (2024)
Druh dokumentu: article
ISSN: 0256-4947
0975-4466
DOI: 10.5144/0256-4947.2024.296
Popis: BACKGROUND: Type 2 diabetes mellitus (T2DM) is a widespread chronic disease that poses a significant management challenge due to the complexity of the associated medication regimens, which can have a considerable impact on patient outcomes. OBJECTIVES: Explore the complexity level of diabetes medications among patients with T2DM and to identify the predictors of medication regimen complexity (MRC) and its correlation with hemoglobin A1C (HbA1c) levels. DESIGN: Retrospective, cross-sectional study SETTING: An ambulatory care setting of a tertiary hospital in Makkah City, Saudi Arabia PATIENTS AND METHODS: Patients with T2DM referred to the diabetic clinic were identified and assessed for eligibility. The data were collected from patient electronic medical records between October 2022 and September 2023. The MRC Index was used to evaluate the complexity of the patients’ medication regimens. MAIN OUTCOMES MEASURES: MRC index scores and HbA1c levels SAMPLE SIZE: 353 records of patients with T2DM RESULTS: The analysis revealed that 61.8% (n=218) of patients had high MRC, with the dosing frequency contributing significantly to their MRC (mean=3.9, SD=1.9). Having polypharmacy and longstanding T2DM were predictors of high MRC (odds ratios=4.9 and 2.6, respectively; P≤.01). Additionally, there was an inverse association between the patients’ diabetes-specific MRC index scores and their glycemic control (odds ratios=0.2, P
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