Characterization and evaluation of liver fibrosis grade in patients with chronic hepatitis B virus infection and normal transaminases
| Autor: | San Juan López Cristina, Casado Martín Marta, González Sánchez Mercedes, Porcel Martín Almudena, Hernández Martínez Álvaro, Vega Sáenz Jose Luis, Parrón Carreño Tesifón |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Clinical and Molecular Hepatology, Vol 24, Iss 4, Pp 384-391 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2287-2728 2287-285X |
| DOI: | 10.3350/cmh.2018.0004 |
| Popis: | Background/Aims The objective of our study was to determine the epidemiological, laboratory, and serological characteristics of patients with chronic hepatitis B virus (HBV) infection and normal transaminases. The study also aimed to evaluate liver damage by measuring the liver fibrosis (LF) grade and to identify possible factors associated with the presence of fibrosis. Methods A retrospective observational study was conducted in patients with chronic HBV infection and classified as inactive carriers or immune-tolerant. Epidemiological variables of age, sex, immigrant, alcohol consumption, and body mass index (BMI), as well as virological variables (HBV DNA) and transaminase level were collected throughout the follow-up. The LF grade was evaluated by transient elastography. The cutoff value for significant fibrosis (SF) was liver stiffness ≥7.9 kPa. Results A total of 214 patients were included in the analysis, and 62% of them had a BMI ≥25 kg/m2. During follow-up, 4% of patients showed transaminase elevation ( |
| Databáze: | Directory of Open Access Journals |
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