An Efficient Preparation of 1,2-Diamino-1-phenylheptane
| Autor: | P. T. Perumal, S. Thennarasu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: | |
| Zdroj: | Molecules, Vol 7, Iss 6, Pp 487-493 (2002) |
| Druh dokumentu: | article |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/70600487 |
| Popis: | A convenient four-step method for the preparation of the lipophilic vicinal diamine 1,2-diamino-1-phenylheptane is described. Condensation involving octan-2-one, benzaldehyde and ammonia is reported. Regioselective Schmidt rearrangement of 2,6-diphenyl-3-pentyl-piperidin-4-one (1) to 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one (3) is presented. Hydrolysis of 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one to 1,2-diamino-1-phenylheptane (4) is also reported for the first time. |
| Databáze: | Directory of Open Access Journals |
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