Bortezomib-Induced Complete Heart Block and Myocardial Scar: The Potential Role of Cardiac Biomarkers in Monitoring Cardiotoxicity

Autor:	Sachin Diwadkar, Aarti A. Patel, Michael G. Fradley
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Case Reports in Cardiology, Vol 2016 (2016)
Druh dokumentu:	article
ISSN:	2090-6404 2090-6412
DOI:	10.1155/2016/3456287
Popis:	Bortezomib is a proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. Traditionally, bortezomib was thought to have little cardiovascular toxicity; however, there is increasing evidence that bortezomib can lead to cardiac complications including left ventricular dysfunction and atrioventricular block. We present the case of a 66-year-old man with multiple myeloma and persistent asymptomatic elevations of cardiac biomarkers who developed complete heart block and evidence of myocardial scar after his eighth cycle of bortezomib, requiring permanent pacemaker placement. In addition to discussing the cardiovascular complications of bortezomib therapy, we propose a potential role for biomarkers in the prediction and monitoring of bortezomib cardiotoxicity.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/27a3867284af4328a1f5c1fb8f66d91d Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF