Dynamics of brain natriuretic peptide in critically ill patients with severe sepsis and septic shock

Autor: Amr S Omar, Masood ur Rahman, Gurdeep S Dhatt, Gubril O Salami, Said Abuhasna
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Saudi Journal of Anaesthesia, Vol 7, Iss 3, Pp 270-276 (2013)
Druh dokumentu: article
ISSN: 1658-354X
DOI: 10.4103/1658-354X.115347
Popis: Purpose: Changes of B-type natriuretic peptide (BNP) in sepsis and its utility in predicting intensive care unit outcomes remains a conflicting issue. To investigate the changes in plasma levels of BNP in patients with severe sepsis/septic shock and to study the association of BNP levels with the severity of the disease and prognosis of those patients. Methods: Thirty patients with severe sepsis or septic shock were enrolled in our study. BNP measurements and echocardiography were carried out on admission and on 4 th and 7 th days. Blood concentrations of BNP were measured by commercially available assays (Abbott methods). In-hospital mortality and length of stay were recorded multivariate analyses adjusted for acute physiology and chronic health evaluation score II (APACHE II score) was used for mortality prediction. Results: Twenty patients admitted with the diagnosis of severe sepsis and 10 patients with septic shock. The in-hospital mortality was 23.3% (7 patients). Admission BNP was significantly higher in the non-survivors 1123±236.08 versus 592.7±347.1 ( P
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