Heme Oxygenase Induction Suppresses Hepatic Hepcidin and Rescues Ferroportin and Ferritin Expression in Obese Mice
| Autor: | Nitin Puri, Yevgeniy Arefiev, Robert Chao, David Sacerdoti, Hibba Chaudry, Alexandra Nichols, Krithika Srikanthan, Athar Nawab, Dana Sharma, Vishal Hari Lakhani, Rebecca Klug, Komal Sodhi, Stephen J. Peterson |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Journal of Nutrition and Metabolism, Vol 2017 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2090-0724 2090-0732 |
| DOI: | 10.1155/2017/4964571 |
| Popis: | Hepcidin, a phase II reactant secreted by hepatocytes, regulates cellular iron levels by increasing internalization of ferroportin-a transmembrane protein facilitating egress of cellular iron. Chronic low-grade inflammatory states, such as obesity, have been shown to increase oxidative stress and enhance hepcidin secretion from hepatocytes and macrophages. Heme-heme oxygenase (HO) is a stress response system which reduces oxidative stress. We investigated the effects of HO-1 induction on hepatic hepcidin levels and on iron homeostasis in hepatic tissues from lean and obese mice. Obese mice exhibited hyperglycemia (p |
| Databáze: | Directory of Open Access Journals |
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