Enantioselective Michael Addition of Aldehydes to Maleimides Organocatalyzed by a Chiral Primary Amine-Salicylamide

Autor:	Alejandro Torregrosa-Chinillach, Adrien Moragues, Haritz Pérez-Furundarena, Rafael Chinchilla, Enrique Gómez-Bengoa, Gabriela Guillena
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	organocatalysis asymmetric synthesis Michael addition maleimides aldehydes Organic chemistry QD241-441
Zdroj:	Molecules, Vol 23, Iss 12, p 3299 (2018)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules23123299
Popis:	A primary amine-salicylamide derived from chiral trans-cyclohexane-1,2-diamine was used as an organocatalyst for the enantioselective conjugate addition of aldehydes, mainly α,α-disubstituted to N-substituted maleimides. The reaction was performed in toluene as a solvent at room temperature. The corresponding enantioenriched adducts were obtained with high yields and enantioselectivities up to 94%. Theoretical calculations were used to justify the stereoinduction.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/27901436b6bd40a8bb3ecd2ebc8bad6b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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