| Autor: |
Emilio Fernández-Espejo, Ana L. Gavito, Juan Suárez, Eduardo Tolosa, Dolores Vilas, Iban Aldecoa, Joan Berenguer, Antonio Córdoba-Fernández, Fátima Damas-Hermoso, Fernando Rodríguez de Fonseca |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Clinical Parkinsonism & Related Disorders, Vol 7, Iss , Pp 100163- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2590-1125 |
| DOI: |
10.1016/j.prdoa.2022.100163 |
| Popis: |
Background: ATP13A2 holds promise as biomarker for Parkinsońs disease (PD). No study has examined how salivary ATP13A2 is related to motor features in idiopathic PD. Methods: Salivary ATP13A2 concentration was evaluated with ELISA, and statistical correlations of ATP13A2 level with PD parameters were examined. The dose intensity of the dopaminergic medication regimen was expressed as levodopa equivalent daily dose (LEDD). ATP13A2 expression on histological sections of submandibular glands was evaluated using immunohistochemistry. Results: Salivary ATP13A2 was undetectable in many subjects (28 % of patients, 43.7 % of controls). However, all the patients with motor complications (n = 28) showed quantifiable levels of ATP13A2, that positively correlated with MDS-UPDRS (total, parts III and IV), and LEDD (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
