Correlation of Sperm DNA Fragmentation Index With Semen Parameters, Lifestyle and Clinical Pregnancy Outcome After Intracytoplasmic Injection
| Autor: | Mahbod Ebrahimi, Firoozeh Akbari Asbagh, Mojgan Tavakoli, Nasim Eshraghi, Naghmeh Poormand, Marjan Ghaemi |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of Family and Reproductive Health, Vol 18, Iss 2 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1735-8949 1735-9392 |
| DOI: | 10.18502/jfrh.v18i2.15936 |
| Popis: | Objective: This study aimed to measure the correlation of sperm DNA fragmentation with semen parameters, lifestyle, and fertility outcomes after intracytoplasmic injection (ICSI). Materials and methods: The partners who were candidates for ICSI with a history of one In vitro fertilization (IVF) failure or male factor were recruited in the study. Semen parameters including sperm count, motility, and morphology as well as DNA fragmentation index (DFI) (that were divided into 2 groups as high (>15%), and low (≤15%) fragmentation scales) were evaluated either. The correlation of DFI with semen parameters, lifestyle, and clinical pregnancy after ICSI were compared between groups. Results: In 120 included couples, 59 men (49.2%) had DFIs ≤ 15% and 61 (50.8%) cases had DFIs >15%. In the group with higher DFI, abnormal morphology (p=0.010) was higher whereas, progressive motility (p=0.001), total motility (p15% was associated with higher values of progressive motility (OR=0.97, p=0.001), total motility (OR=0.96, p=15% (OR=3.37, p=0.046). Although no correlation was found between male age and lifestyle components with DFI, the number of embryos was lower in DFI≥15% (p |
| Databáze: | Directory of Open Access Journals |
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