| Autor: |
Sabrina Collin, Russell J. Cox, Cédric Paris, Christophe Jacob, Benjamin Chagot, Kira J. Weissman, Arnaud Gruez |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-023-36974-3 |
| Popis: |
Biosynthesis of complex polyketides by polyketide synthases often relies on trans-acting enzymes to modify the intermediates. Here, the authors elucidate how β-methylation enzymes identify their substrates. The recognition is imperfect, resulting in a doubly β-methylated virginiamycin derivative. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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