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Objectives Vaccine hesitancy persists as a significant global health concern, especially during public health crises. This study aimed to explore factors influencing vaccination acceptance during a major public health crisis and establish a model of influencing factors.Design A cross-sectional study.Methods An anonymous cross-sectional survey was conducted online, encompassing sociodemographic characteristics, anxiety levels, personal risk perception and attitudes towards vaccination acceptance. Data analysis was performed using t-tests, one-way analysis of variance and multiple linear regression techniques in IBM SPSS Statistics V.25.0 (IBM Corp., Armonk, NY, USA).Results A total of 3921 participants participated in the survey. The mean acceptance attitudes were above the moderate level (M=4.02, SD=0.51), the mean risk perception score was below the moderate level (M=2.66, SD=0.58), and the mean score on the Self-Rating Anxiety Scale was also below the moderate level (M=2.05, SD=0.53). The results showed that internal variables (gender, age, marital status, professional background, region) and external variables (average family income, distance from home to vaccination site, family medical background) were statistically significant (p |