A Virtual Staining Method Based on Self-Supervised GAN for Fourier Ptychographic Microscopy Colorful Imaging

Autor: Yan Wang, Nan Guan, Jie Li, Xiaoli Wang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Applied Sciences, Vol 14, Iss 4, p 1662 (2024)
Druh dokumentu: article
ISSN: 2076-3417
DOI: 10.3390/app14041662
Popis: Fourier ptychographic microscopy (FPM) is a computational imaging technology that has endless vitality and application potential in digital pathology. Colored pathological image analysis is the foundation of clinical diagnosis, basic research, and most biomedical problems. However, the current colorful FPM reconstruction methods are time-inefficient, resulting in poor image quality due to optical interference and reconstruction errors. This paper combines coloring and FPM to propose a self-supervised generative adversarial network (GAN) for FPM color reconstruction. We design a generator based on the efficient channel residual (ECR) block to adaptively obtain efficient cross-channel interaction information in a lightweight manner, and we introduce content-consistency loss to learn the high-frequency information of the image and improve the image quality of the staining. Furthermore, the effectiveness of our proposed method is demonstrated through objective indicators and visual evaluations.
Databáze: Directory of Open Access Journals