| Autor: |
Suvajdžić-Vuković Nada D., Pandurović Radmila, Rajić Zoran, Milošević Rajko, Bogdanović Andrija D., Lazarević Vladimir, Elezović Ivo V., Čolović Milica R., Budišin Živko, Savić Nebojša S., Vučelić Dragica, Vavić Nataša, Bošković Darinka V. |
| Jazyk: |
English<br />Serbian |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
Vojnosanitetski Pregled, Vol 61, Iss 6, Pp 621-627 (2004) |
| Druh dokumentu: |
article |
| ISSN: |
0042-8450 |
| DOI: |
10.2298/VSP0406621S |
| Popis: |
Thirty-six patients (pts.) with thrombotic thrombocytopenic purpura (TTP) were treated between May 1990 and May 2003. There were 31 women and 5 men; the average age was 37 years. Twenty-five cases were idiopathic and 11 secondary (3 infection - related, 5 occurred during pregnancy and 3 were drug - associated). The mean lag period between the first symptoms and the diagnosis was 8.5 days (in 14 pts. £ 5; in 22 > 5). On diagnosis neurological symptoms were present in 31, bleeding in 33, fever in 21 and renal impairment in 27 patients. The mean hemoglobin was 67.5 g/L, the mean platelet count was 10´109/L, and the mean reticulocytosis was 17%. The mean serum LDH was 1457 IU. Treatment included plasma exchange (PE) in 24 pts. and only plasma infusions in 12 pts. There were 24 complete responders (20 on PE) and 12 deaths (4 on PE); PE significantly improved survival (p5 days), the secondary form of TTP and the absence of coma at presentation. The use of PE significantly improved survival. TTP is a severe disorder requiring early recognition and diagnosis in general medical care facilities, which should lead to the timely treatment with PE. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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