Sorafenib-induced acute pancreatitis

Autor: Han-En Wang, Chun-Ting Chen, Hsin-Hung Huang
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Journal of Medical Sciences, Vol 34, Iss 3, Pp 126-128 (2014)
Druh dokumentu: article
ISSN: 1011-4564
DOI: 10.4103/1011-4564.134392
Popis: Sorafenib was approved in 2005 for the treatment of metastatic renal cell carcinoma and advanced hepatocellular carcinoma (HCC). Acute pancreatitis is a side-effect of sorafenib usage. We present a patient with advanced HCC who presented with acute Grade D pancreatitis caused by sorafenib administration. Following the discontinuation of sorafenib, fasting, and fluid replacement, the patient′s clinical manifestation of Grade D pancreatitis subsided in a short time. One month after discharge, she resumed sorafenib treatment (200 mg/day) due to disease progression. Based on this experience, resumption of sorafenib treatment appears to be safe.
Databáze: Directory of Open Access Journals