| Autor: |
Graeme O'Connor, Yuxin Sun, Breeana Gardiner, Grace Audu, Mona Bajaj-Elliott, Simon Eaton |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Clinical Nutrition Open Science, Vol 53, Iss , Pp 1-10 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2667-2685 |
| DOI: |
10.1016/j.nutos.2023.12.002 |
| Popis: |
Summary: Background: Non-digestible dietary fiber undergoes fermentation by the intestinal microbiota to produce short-chain fatty acids (SCFAs). Intestinal SCFAs control the production of T-helper cells, antibodies and are involved in maintaining homeostasis of the mucosal system. Sepsis is the leading cause of mortality in hospitalised children and is treated with antibiotics which disrupts the normal maturation of the microbiome causing dysbiosis. This study assessed the impact of a high-fibre Food-Based formula on feed tolerance and faecal SCFA concentrations in children admitted to intensive care with sepsis. Methods: An open-label single-subject study was based on repeated observations over 14 days in children admitted to intensive care with sepsis who commenced a high-fiber Food-Based enteral formula Compleat®Paediatric, (Nestle Health Science). Stool samples were collected to measure SCFA concentrations (acetate, butyrate and propionate). A Wilcoxon Signed-Rank test was used to measure change in SCFA concentrations. Other data collection included feed tolerance, anthropometrics, antibiotic administration and inflammatory markers. Results: Twenty children with sepsis were recruited over six months. The mean age was 10.8 years (±5.6 years SD). The most common sepsis-related organ failure was the respiratory tract (50 %). The mean duration of mechanical ventilation was 9 days (±4 SD), 25 % of children were treated with more than two antibiotics during their time in intensive care. Faecal propionate and butyrate concentrations were maintained during the children's time in intensive care. Stool frequency reduced from 2.6 per day (±1.08 SD) at baseline to 1.2 per day (±0.45 SD) after one week in intensive care (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
