Regulation of Caenorhabditis Elegans model in Alzheimer’s Disease
| Autor: | Jing Yuxuan |
|---|---|
| Jazyk: | English<br />French |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | E3S Web of Conferences, Vol 185, p 03043 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2267-1242 20201850 23242329 |
| DOI: | 10.1051/e3sconf/202018503043 |
| Popis: | Alzheimer’s disease (AD) is affecting numerous families and individuals around the world nowadays, as the exact reason is still undetermined. At this stage, developmental treatment displays a particularly significant role in relieving symptoms for the patients. Currently, the two most well-known factors that have impacts on the diagnosis of AD are the plaques and tangles formed from amyloid-beta and tau protein. Modelling for Alzheimer’s disease is essential in understanding targeted aspects of the disease, while Caenorhabditis elegans (C.elegans) was chosen as a pivotal model. C.elegans presents dramatic priorities using orthologs for the study of AD, especially in examining the formation of the deposits and the regulations of specific gene expressions that result in this abnormality. This review discusses the properties, which C.elegans shows on the study of AD, and the achievements that have been approached using this model, as well as what other models are being tested by scientists. Properties of other models, which can overwhelm C.elegans, as well as the expectations for future modelling systems on AD are examined as well. |
| Databáze: | Directory of Open Access Journals |
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