Synthesis and Biological Evaluation of New Bis-Indolinone Derivatives Endowed with Cytotoxic Activity

Autor:	Rita Morigi, Elena Catanzaro, Alessandra Locatelli, Cinzia Calcabrini, Valentina Pellicioni, Alberto Leoni, Carmela Fimognari
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	programmed cell death cell cycle small molecules indolinone systems Knoevenagel reaction Organic chemistry QD241-441
Zdroj:	Molecules, Vol 26, Iss 20, p 6277 (2021)
Druh dokumentu:	article
ISSN:	26206277 1420-3049
DOI:	10.3390/molecules26206277
Popis:	A series of new Knoevenagel adducts, bearing two indolinone systems, has been synthesized and evaluated on 60 human cancer cell lines according to protocols available at the National Cancer Institute (Bethesda, MD, USA). Some derivatives proved to be potent antiproliferative agents, showing GI50 values in the submicromolar range. Compound 5b emerged as the most active and was further studied in Jurkat cells in order to determine the effects on cell-cycle phases and the kind of cell death induced. Finally, oxidative stress and DNA damage induced by compound 5b were also analyzed.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/27446127bdbe46449fe615bbc4ee3fa3 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF