Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness

Autor: Leo E. Wong, Arshiya Bhatt, Philipp S. Erdmann, Zhen Hou, Joachim Maier, Sona Pirkuliyeva, Michael Engelke, Stefan Becker, Jürgen Plitzko, Jürgen Wienands, Christian Griesinger
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-14544-1
Popis: Antibody-mediated immune responses rely on antigen recognition by the B cell antigen receptor (BCR) and SLP65 is a key scaffold protein mediating BCR signaling. Here authors show that effective B cell activation requires tripartite phase separation of SLP65, CIN85, and lipid vesicles.
Databáze: Directory of Open Access Journals