| Autor: |
Andrea Marino, Antonio Munafò, Egle Augello, Carlo Maria Bellanca, Carmelo Bonomo, Manuela Ceccarelli, Nicolò Musso, Giuseppina Cantarella, Bruno Cacopardo, Renato Bernardini |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Infectious Disease Reports, Vol 14, Iss 3, Pp 360-371 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2036-7449 |
| DOI: |
10.3390/idr14030040 |
| Popis: |
Two years have passed since WHO declared a pandemic state for SARS-CoV-2 infection. COVID-19 pathogenesis consists of a first viral phase responsible for early symptoms followed by an inflammatory phase, cytokine-mediated, responsible for late-onset manifestations up to ARDS. The dysregulated immune response has an outstanding role in the progression of pulmonary damage in COVID-19. IL-6, through the induction of pro-inflammatory chemokines and cytokines, plays a key role in the development and maintenance of inflammation, acting as a pioneer of the hyperinflammatory condition and cytokine storm in severe COVID-19. Therefore, drugs targeting both IL-6 and IL-6 receptors have been evaluated in order to blunt the abnormal SARS-CoV-2-induced cytokine release. Sarilumab, a high-affinity anti-IL-6 receptor antibody, may represent a promising weapon to treat the fearsome hyperinflammatory phase by improving the outcome of patients with moderate-to-severe COVID-19 pneumonia. Further prospective and well-designed clinical studies with larger sample sizes and long-term follow-up are needed to assess the efficacy and the safety of this therapeutic approach to achieve improved outcomes in COVID-19. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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