MiR‐10a‐5p restrains the aggressive phenotypes of ovarian cancer cells by inhibiting HOXA1

Autor: Li‐Jun Liu, Xiao‐Yan Sun, Chen‐Xi Yang, Xiao‐Yan Zou
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Kaohsiung Journal of Medical Sciences, Vol 37, Iss 4, Pp 276-285 (2021)
Druh dokumentu: article
ISSN: 2410-8650
1607-551X
DOI: 10.1002/kjm2.12335
Popis: Abstract MicroRNAs (miRNAs) are dysregulated in human ovarian carcinoma (OC). But the mechanism underlying miR‐10a‐5p in regulating the progression of OC need deeply explored. In the current study, we observed that miR‐10a‐5p was down‐expressed in OC samples and OC cell lines. In addition, miR‐10a‐5p restrained the viability, colony formation, migration ability and invasiveness of OC cells. We further ascertained Homeobox A1 (HOXA1) was a downstream gene of miR‐10a‐5p. Furthermore, HOXA1 was distinctly upregulated in OC samples. Finally, upregulation of HOXA1 abolished the suppressive effects of miR‐10a‐5p on OC cells. These observations suggested that miR‐10a‐5p suppressed the aggressive phenotypes of OC cells via regulating HOXA1.
Databáze: Directory of Open Access Journals
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