Long-term exercise training down-regulates m6A RNA demethylase FTO expression in the hippocampus and hypothalamus: an effective intervention for epigenetic modification

Autor: Shu-Jing Liu, Tong-Hui Cai, Chun-Lu Fang, Shao-Zhang Lin, Wen-Qi Yang, Yuan Wei, Fu Zhou, Ling Liu, Yuan Luo, Zi-Yi Guo, Ge Zhao, Ya-Ping Li, Liang-Ming Li
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Neuroscience, Vol 23, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 1471-2202
DOI: 10.1186/s12868-022-00742-8
Popis: Abstract Background Exercise boosts the health of some brain parts, such as the hippocampus and hypothalamus. Several studies show that long-term exercise improves spatial learning and memory, enhances hypothalamic leptin sensitivity, and regulates energy balance. However, the effect of exercise on the hippocampus and hypothalamus is not fully understood. The study aimed to find epigenetic modifications or changes in gene expression of the hippocampus and hypothalamus due to exercise. Methods Male C57BL/6 mice were randomly divided into sedentary and exercise groups. All mice in the exercise group were subjected to treadmill exercise 5 days per week for 1 h each day. After the 12-week exercise intervention, the hippocampus and hypothalamus tissue were used for RNA-sequencing or molecular biology experiments. Results In both groups, numerous differentially expressed genes of the hippocampus (up-regulated: 53, down-regulated: 49) and hypothalamus (up-regulated: 24, down-regulated: 40) were observed. In the exercise group, increased level of N6-methyladenosine (m6A) was observed in the hippocampus and hypothalamus (p
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