Polyphosphoric Acid-Promoted Efficient Synthesis of Cinnamides via Aldol Condensation of Amide

Autor:	Enhua Wang, Lishou Yang, Lanfeng He, Qian Yang, Xue Wang, Yunlu Liu, Manxiang Li, Yang Lei, Xiaosheng Yang
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	polyphosphoric acid cinnamide aldol condensation amide Organic chemistry QD241-441
Zdroj:	Molecules, Vol 29, Iss 19, p 4632 (2024)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules29194632
Popis:	Cinnamides are common core structures that exist in a great number of pharmaceuticals and natural products. The development of efficient methods for preparing cinnamides is in great need. We report herein an efficient polyphosphoric acid (PPA)-promoted direct aldol condensation of an amide for the convenient and straightforward preparation of cinnamides. A variety of cinnamides were obtained in moderate-to-excellent yields (65–89%). This strategy features the use of equivalent amides and a short reaction time.
Databáze:	Directory of Open Access Journals
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