Cost-Effectiveness of Clomiphene Citrate-Based Minimal Stimulation Compared with Controlled Ovarian Stimulation Protocol in Women with Diminished Ovarian Reserve
| Autor: | Shogo Nishii, Ryosuke Akino, Linji Chen, Nana Nishioka, Hiroki Nakabayashi, Akihiko Tabuchi, Miwa Sakamoto, Tetsuro Kondo, Akihiko Sekizawa |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Fertility & Reproduction, Vol 06, Iss 03, Pp 128-134 (2024) |
| Druh dokumentu: | article |
| ISSN: | 26613182 2661-3174 2661-3182 |
| DOI: | 10.1142/S266131822450018X |
| Popis: | Background: In Japan, where infertility treatment is now covered by insurance, appropriate protocols for patients with diminished ovarian reserve (DOR) based on treatment outcomes and cost-effectiveness must be selected. Therefore, this study aims to provide information on the outcomes and cost-effectiveness of conventional ovarian stimulation and mild stimulation for patients with DOR in Japan. Methods: Data from 66 women who underwent first oocyte retrieval at Showa University Hospital between May 2019 and November 2023 were analyzed. Results: The clomiphene citrate (CC) group used significantly fewer gonadotropins and incurred lower costs than the conventional ovarian stimulation group while achieving comparable clinical outcomes, including cumulative live birth rates. Conclusions: CC-based minimal stimulation is a cost-effective alternative to conventional ovarian stimulation for patients with low ovarian reserve without compromising clinical efficacy. Further randomized controlled trials are required to confirm these findings and optimize protocols for this population. |
| Databáze: | Directory of Open Access Journals |
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