Liver stiffness and spleen stiffness predict distinct liver-related events after hepatitis C eradication with direct-acting antivirals

Autor: Sheng-Hung Chen, Hsueh-Chou Lai, Wen-Pang Su, Jung-Ta Kao, Wei-Fan Hsu, Hung-Wei Wang, Hung-Yao Chen, Cheng-Yuan Peng
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of the Formosan Medical Association, Vol 123, Iss 12, Pp 1279-1286 (2024)
Druh dokumentu: article
ISSN: 0929-6646
DOI: 10.1016/j.jfma.2024.02.016
Popis: Background: Purpose: This study aimed to directly compare the utility of liver stiffness (LS) and spleen stiffness (SS) at sustained virologic response (SVR) for predicting hepatocellular carcinoma (HCC) and non-HCC events in patients with chronic hepatitis C (CHC) after direct-acting antiviral therapy. Methods: This retrospective study included 695 CHC patients who achieved SVR and underwent LS and SS measurements. LS and SS were measured using point shear wave elastography and compared head-to-head. Results: During a median follow-up of 29.5 months, 49 (7.1%) patients developed liver-related events (LREs), including 28 HCC and 22 non-HCC events after SVR. Multivariable Cox regression analysis revealed that age, albumin level, and LS (≥ versus
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